Ivabradine Hydrochloride (S)-Mandelic Acid Co-Crystal: In Situ Preparation during Formulation

preparation of smart in situ gel forming polymeric nanomicelles for prolonged release of naltrexone hydrochloride

Study of the Formulation Parameters Affecting the Preparation of Microencapsulated Ion-Exchange Resins Containing Venlafaxine Hydrochloride

Venlafaxine is a novel, non-tricyclic antidepressant. Venlafaxine imparts its antidepressant effects by inhibiting the neuronal uptake of norepinephrine, serotonin and to a lesser extent, dopamine1. It lacks monoamine oxidase activity and, more importantly, lacks the adverse effect profile of tricyclic antidepressants. Now, there has been the sustained-release preparation of this drug coming in...

Stereoselective biotransformation of racemic mandelic acid using immobilized laccase and (S)-mandelate dehydrogenase

OBJECTIVES (S)-Mandelate dehydrogenase (SMDH) and laccase were immobilized on chitosan. The bi-enzymatic system with immobilized SMDH and immobilized laccase was taken to catalyze the stereoselective transformation of racemic mandelic acid and (R)-mandelic acid was obtained from its racemic mixture. RESULTS Characteristics of the immobilized enzymes were valuated. The optimum pH and temperatu...

In situ observation of antisite defect formation during crystal growth.

In situ x-ray diffraction (XRD) coupled with molecular dynamics (MD) simulations have been used to quantify antisite defect trapping during crystallization. Rietveld refinement of the XRD data revealed a marked lattice distortion which involves an a axis expansion and a c axis contraction of the stable C11b phase. The observed lattice response is proportional in magnitude to the growth rate, su...

Mandelic Acid in the Treatment of Urinary Infections.